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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T32189 |
Iproplatin
JM-9,CHIP,Code name: JM9,JM 9 |
||
Iproplatin is a synthetic second-generation platinum-containing compound related to cisplatin. Iproplatin binds to and forms DNA crosslinks and platinum-DNA adducts, resulting in DNA replication failure and cell death. Although less prone to glutathione i |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-01386 |
STUB1 Protein, Human, Recombinant
Carboxy Terminus of Hsp<... |
Human | E. coli |
E3 Ubiquitin-Protein Ligase CHIP is a cytoplasmic protein. CHIP is highly expressed in skeletal muscle, heart, pancreas, brain and placenta. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain; lead to in client substrate ubiquitylation and degradation by the proteasome. CHIP targets misfolded chaperone substrates towards proteasomal degradation. CHIP mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation.... |